Lance Armstrong
Lance Armstrong is a four-time winner of the Tour de France at the time this book was written. This book covers his life's experiences with cancer and cycle racing up until winning the 2000 Tour de France.

Latrice Haney
Armstrong's head nurse during his recovery from cancer. Armstrong recounts her as being sweet and friendly.

Kristin Richards/ Kik/Kristin Armstrong
Lance Armstrong's PR manager for his charity event who later became his wife. They had one child together in the book, but had two more later.

OTHER CHARACTERS
Dr. Scott Shapiro
Armstrong's surgeon who helped remove the lesions in his brain and lungs.
Dr. Steve Wolff
Armstrong's medical reference and friend during his healing process.
Bill Stapleton
Lance Armstrong's agent and was one of the first people to know he had cancer.